|
KMID : 1143120220120010009
|
|
Asia Pacific Allergy
2022 Volume.12 No. 1 p.9 ~ p.9
|
|
|
Cytokine release syndrome - a unique entity of Augmentin hypersensitivity reaction
|
|
Tan Lynette Liling
Lee May Ping
Goh Si Hui
Lim Hwee Hoon
Goh Anne
Chong Kok Wee
|
|
|
Abstract
|
|
|
|
Cytokine release syndrome (CRS) is a type of hypersensitivity reaction which has been previously described with chemotherapy and monoclonal antibodies, but not with antibiotics. We present 2 pediatric cases of Amoxicillin/Clavulanic acid (Augmentin) anaphylaxis resembling CRS. Both our patients presented during the index reaction with symptoms suggestive of an acute systemic inflammatory response mimicking sepsis. Their symptomology was reproducible at drug provocation test as anaphylaxis, but with suboptimal response to intramuscular adrenaline. Their infective workups were unremarkable and illnesses followed a self-limiting course. All these point towards a severe hypersensitivity reaction resembling CRS.
|
|
|
KEYWORD
|
|
|
Drug hypersensitivity, Cytokine release syndrome, Amoxicillin-potassium clavulanate combination
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|